workbook.Save("C:\Orders.xls")
After setting all options and cell values, the last thing you need to do with your workbook is write it to a file so it can be opened in Microsoft® Excel®. This is easily performed with the Save method of Workbook object. You can write the workbook to a stream or have it automatically create an xls file for itself.
The following code shows how to write your workbook to a file once you are done creating it.
In Visual Basic:
workbook.Save("C:\Orders.xls")
In C#:
workbook.Save( "C:\\Orders.xls" );