Unfortunately, this isn't directly supported, but can be accomplished. I would recommend submitting a feature request for this to the support group: http://devcenter.infragistics.com/Protected/RequestFeature.aspx.

To accomplish this manually, you can do the following (assuming you're doing it to ButtonTool1 which has a shortcut of Ctrl+S):

1. Set the SharedProps.Shortcut of ButtonTool1 to None.

2. Set the SharedProps.ToolTipText of ButtonTool1 to <the caption or whatever other text you want to describe the button> + " (" + TypeDescriptor.GetConverter( typeof( Keys ) ).ConvertToString( (Keys)Shortcut.CtrlS ) + ")".

3. If the code handling ButtonTool1's click is in the main ToolClick event handler:

    a. Move the code handling the ButtonTool1 click from the ToolClick event handler into its own method.

    b. Add a call to the new ButtonTool1 click handler method when the code was in the ToolClick event handler.

4. Override ProcessDialogKey in your form with the following code:

protected override bool ProcessDialogKey( Keys keyData )
{
 if ( keyData == (Keys)Shortcut.CtrlS )
 {
  // Call ButtonTool1 click handler method
  return true;
 }

 return base.ProcessDialogKey( keyData );
}