Hello Will,

The issue happens because you should do a postback in order to make the changes have effect.

I can suggest you two options:

1) When you set the WebPanel to be enabled you should iterate through the controls and enable them

For example:

        function WebDropDown1_SelectionChanging(sender, eventArgs) { 

            var text = eventArgs.getNewSelection()[0].get_text();

            var panel = igpnl_getPanelById('WebPanel1');

            var chooser = igdrp_getComboById("<% =WebDateChooser1.ClientID %>");

            if (text == "Enabled") {

                panel.setEnabled(true);

                chooser.setEnabled(true);

            }

            else {

                panel.setEnabled(false);

                chooser.setEnabled(false);

            }

        }

2) Wrap the Controls inside update panel and turn on the AutoPostBackFlags-SelectionChanged  of the WebDropDown

        <asp:UpdatePanel ID="UpdatePanel1" runat="server">

            <ContentTemplate>

                <ig:WebDropDown ID="WebDropDown1" runat="server" Width="200px" OnSelectionChanged="WebDropDown1_SelectionChanged">

                    <Items>

                        <ig:DropDownItem Selected="False" Text="Enabled" Value="">

                        </ig:DropDownItem>

                        <ig:DropDownItem Selected="False" Text="Disabled" Value="">

                        </ig:DropDownItem>

                    </Items>

                    <AutoPostBackFlags SelectionChanged="On" />

                    <ClientEvents SelectionChanging="WebDropDown1_SelectionChanging" />

                </ig:WebDropDown>

                <igmisc:WebPanel ID="WebPanel1" runat="server">

                    <Template>

                        <igsch:WebDateChooser ID="WebDateChooser1" runat="server">

                        </igsch:WebDateChooser>

                        <asp:TextBox ID="TextBox1" runat="server"></asp:TextBox>

                        <ig:WebCaptcha ID="WebCaptcha1" runat="server" Width="250px">

                        </ig:WebCaptcha>

                        <asp:RadioButtonList ID="RadioButtonList1" runat="server">

                            <asp:ListItem>1</asp:ListItem>

                            <asp:ListItem>2</asp:ListItem>

                            <asp:ListItem>3</asp:ListItem>

                        </asp:RadioButtonList>

                    </Template>

                </igmisc:WebPanel>

            </ContentTemplate>

        </asp:UpdatePanel>

Please let me know if you need further assistance regarding this.