TabItems will register mnemonics based on the header text when there is an underscore (assuming the ContentPresenter within the template has its RecognizesAccessKey set to true) but there is no built in support for arbitrary shortcuts. You could probably create your own command and then add KeyBindings to the InputBindings of the control or perhaps write an attached behavior that will hook the keydown of the target and set the SelectedIndex of the Selector (the xamTabControl in this case) to that value. Note these would only work when the control itself has keyboard focus or keyboard focus is within the control otherwise it would not receive key events.