I didn't try this so I can't promise it will work, but EditorWithCombo just happens to expose a virtual method, 'OnTextBoxMouseWheel', which you can override if you derive a class from EditorWithCombo and embed that in the grid instead of the UltraComboEditor control. Instead of setting the column's EditorControl property, you would assign an instance of your derived editor to the Editor property. In the OnTextBoxMouseWheel implementation, check this.IsDroppedDown (and/or whatever other criteria you have) and if you want to "cancel" the wheeling on the editor, upcast the MouseEventArgs instance to a HandledMouseEventArgs, and set the Handled property to true. This will cause the editor to forego its mouse wheel logic, and by doing that, the grid will know to process it.